Mayo Clinic in Space: To Make Space Travel Safer
Discovery's Edge is Mayo Clinic's research magazine, offering insight into the process and progress of medical science at the world's largest group medical practice. This article was reprinted with permission from Discovery's Edge. Learn more at discoverysedge.mayo.edu.
It's a long way to Mars. And nearly all the journey is outside of Earth's semiprotective atmosphere. Even the International Space Station, 248 miles up, is in a relatively safe orbit — meaning radiation and other exposures are limited.
Still, all the astronauts who have spent more than six consecutive months in space have experienced early symptoms of aging, ranging from shortened telomeres on their chromosomes to cancer. All had a greater-than-normal percentage of cells linked to aging. Heart damage is also a risk to those who travel in zero gravity conditions and are then reexposed to normal gravity.
That's why two Mayo Clinic scientists have research projects riding shotgun on a rocket ship scheduled to lift off in April.
Andre Terzic, M.D., Ph.D., a Mayo Clinic cardiology researcher, and James Kirkland, M.D., Ph.D., a Mayo Clinic geriatrics expert, are leading two lines of research that will be conducted during the trip and while the four astronauts of the Axiom Space flight are at the space station.
Over 10 days, Larry Connor, an astronaut and pilot, will work with self-contained minilaboratories of cells, maintaining them and recording data. The cells will be analyzed on their return to Earth, as will the astronauts, who were examined by Mayo researchers before the flight and will be tested after the flight.
Cells in Space
Larry spent time at Mayo Clinic conferring with the two researchers and training on laboratory procedures.
"He will be taking these heartlike cells, cultivating them in space, changing their media — feeding them, in other words — and essentially preparing them for very elaborate molecular analysis that will be undertaken upon the return of the shuttle," says Dr. Terzic, the Marriott Family Director of the Comprehensive Cardiac Regenerative Medicine Program in the Mayo Clinic Center for Regenerative Medicine.
While much research has been performed on heart issues in space, this is the first time it will be so focused, Dr. Terzic says.
"There has been no study so far looking very specifically at some genetic variants and the molecular traits of us as individuals on the resilience to cardiac stress and risk for disease. So this is completely new."
The cells provided for the study originated from source material at the Center for Regenerative Medicine. The other cardiac study is a clinical trial involving the astronauts.
"It will monitor the cardiac function of the astronauts, as well as pick up on some of the markers of cardiac health while they are in space," Dr. Terzic says. "There may be some very specific information we bring back, which may indicate that certain individuals are more resilient than others. It may help us understand if our genetic makeup is a criterion in selecting the fittest potential travelers in the future."
Larry, an experienced jet pilot, is a Mayo Clinic benefactor who supported research in these scientific areas long before helping conduct it in space. He is CEO and founder of The Connor Group, an Ohio-based real estate investing firm. This flight and this science are things he takes seriously.
"I wanted to go there to do worthwhile research because in microgravity it's a very unique environment," Larry says. "And what better organization than Mayo Clinic to do it with? I have no interest in being a space tourist."
The flight of the SpaceX Dragon cargo spacecraft is scheduled to lift from Cape Canaveral in April.
Zombie Cells in Space
Senescent cells are sometimes call zombie cells because they can stay around in the body long after they stop functioning, causing deterioration of nearby healthy cells and contributing to a long list of symptoms — all related to aging. Those include osteoporosis, vision problems, heart disease, chronic inflammation, arthritis, frailty, pulmonary fibrosis, renal disease and cancer.
"People returning from space missions — even brief ones — when their blood and bodily fluids are analyzed, there's evidence of DNA damage," says Dr. Kirkland, director of Mayo's Robert and Arlene Kogod Center on Aging and the Noaber Foundation Professor of Aging Research. "There are zero gravity, high-G acceleration forces on takeoff, and then there's radiation in space. All these things can be linked to cellular senescence."
"NASA is very concerned about radiation,” Dr. Kirkland says, “especially the radiation outside the Van Allen belt. And solar flares are also very dangerous in causing cells to become senescent. So our view is that the Mars mission may be very difficult to accomplish, unless we can find ways to monitor for senescent cell burden and unless we can get our senolytics agents perfected."
Senolytics are drugs discovered at Mayo Clinic that can be used to clear senescent cells from the body. Mayo researchers are conducting over 20 clinical trials on a range of diseases and conditions to determine whether or to what degree removing what Dr. Kirkland calls the "senescent burden" can help symptoms of aging or serve as a therapy. Could the drugs be useful to treat future space travelers after a flight, or be used as a precursor to launch? Those are some questions the team hopes to answer.
Crew members will have their senescent cell levels measured prior to liftoff and again on their return to Earth. Larry also will tend to an experiment with human cells to see if they are susceptible to senescence once in space. Those cells will be compared to a control cache kept on the ground at Cape Canaveral.
How soon will the results of the space studies be known?
"Hopefully, we'll have some early answers within a few months afterward," Dr. Kirkland says. "But this is all new. This is like throwing the dice. We'll have to see what we see."
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